If you've ever stayed in a Renaissance Hotel before, you know they're seriously luxurious, comfortable, clean, and always have great staff on hand to cater to your travel needs. They're also, if we're being honest, a bit on the pricey side (but worth it!). But through the end of August, you can save 25% on Renaissance Hotels weekend bookings of 2 or more nights at Hotels.com when you pay with an American Express card. (Stay must include a Friday or a Saturday night). Sale ends 08/31/2011.